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目的:探讨我院药品不良反应(ADR)发生的特点及规律,为临床合理用药及药品安全性评价提供参考。方法:对我院2009-2010年收集到的442例有效ADR报告进行统计、分析。结果:442例ADR报告中,涉及药品159种,60岁以上患者发生ADR的比例最高(138例,占31.22%);静脉注射给药引发的ADR最多(349例,占78.96%);最易引起ADR的药物为抗感染药(209例,占47.29%),其次为中药制剂(64例,14.48%);ADR损害类型主要以皮肤及其附件损害为主(223例,占50.45%),其次为消化系统和心血管系统损害;新的ADR11例,以中药制剂引发的为主;严重ADR32例,以过敏性休克较多(7例,占严重ADR病例的21.88%),其次为肝功能异常和高热。结论:临床应重视和加强ADR监测,合理用药,减少或避免ADR的发生。
Objective: To investigate the characteristics and rules of adverse drug reaction (ADR) in our hospital and to provide reference for clinical rational drug use and drug safety evaluation. Methods: 442 valid ADR reports collected in our hospital from 2009 to 2010 were analyzed statistically. Results: Among 442 ADR cases, 159 kinds of ADRs were reported. The highest ADR occurred in patients over 60 years old (138 cases, accounting for 31.22%). The most ADR was caused by intravenous injection (349 cases, accounting for 78.96%). ADR drugs were anti-infectives (209 cases, accounting for 47.29%), followed by traditional Chinese medicine preparations (64 cases, 14.48%). The main types of ADR injuries were skin and its accessories (223 cases, accounting for 50.45%), Followed by the digestive and cardiovascular system damage; new cases of ADR 11 cases, mainly caused by traditional Chinese medicine preparations; severe ADR32 cases, more anaphylactic shock (7 cases, accounting for 21.88% of severe ADR cases), followed by liver function Abnormal and high fever. Conclusion: Clinical should pay attention to and strengthen the ADR monitoring, rational use of drugs to reduce or avoid the occurrence of ADR.