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目的探讨减少CD3AK细胞输入不良反应的最佳技术操作方法。方法将62例接受CD3AK细胞输入治疗的慢性乙型肝炎患者分为两组:用CD3AK细胞输入与白介素-2混合静脉输入的15例患者为混合输入组,采用CD3AK细胞、白介素-2分别单独静脉输入的47例患者为分开输入组,观察两组输入反应情况。结果两组头痛、发热、畏寒的发生率,经统计学处理,有显著性差异(P<0.01)。结论取CD3AK细胞、白介素-2加入生理盐水分别单独输入的方法,可减轻患者不良反应,顺利完成疗程,达到预期的治疗效果。
Objective To investigate the best technique to reduce the adverse reactions of CD3AK cells. Methods Sixty-two patients with chronic hepatitis B treated with CD3AK cells were divided into two groups. Fifteen patients with CD3AK cells mixed with interleukin-2 (IL-2) were randomly divided into three groups. CD3AK cells and interleukin-2 The 47 patients entered were divided into groups and observed the response of the two groups. Results The incidence of headache, fever and chills in both groups were statistically significant (P <0.01). Conclusion Taking CD3AK cells and interleukin-2 into physiological saline separately can reduce the adverse reactions of patients and successfully complete the course of treatment to achieve the expected therapeutic effect.