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2′-去氧助间型霉素(2′-DOC)是腺苷脱氨酶(AD)的强抑制剂。AD 是一种嘌呤核苷酸代谢酶,它在淋巴细胞中有很高的活性。曾证明当AD 受抑制时,其酶作用物腺苷和脱氧腺苷对培养的淋巴母细胞有毒性作用;在人的恶性淋巴细胞中AD 升高。因此,应用2′-DOC 作为淋巴样恶性病特异性疗法引起人们的注意。据信,2′-DOC 的抗淋巴细胞是通过对腺苷、脱氧腺苷及其代谢产物而产生的作用。AD 的抑制伴有细胞内三磷酸脱氧腺苷的升高和三磷酸腺苷的耗尽。用2′-DOC 治疗的
2’-deoxyco-mycin (2’-DOC) is a strong inhibitor of adenosine deaminase (AD). AD is a purine nucleotide metabolism enzyme that has high activity in lymphocytes. It has been demonstrated that when AD is inhibited, its substrates adenosine and deoxyadenosine have toxic effects on cultured lymphoblasts; AD is elevated in human malignant lymphocytes. Therefore, the application of 2’-DOC as a lymphoid malignancy-specific therapy has attracted attention. It is believed that the anti-lymphocyte of 2’-DOC is produced by adenosine, deoxyadenosine and its metabolites. Inhibition of AD is accompanied by an increase in intracellular deoxyadenosine triphosphate and depletion of adenosine triphosphate. Treated with 2’-DOC