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目的:研制一种新型有效的牙周抗菌制剂,以代替常规用药。方法:用琼脂稀释法做几种口腔常见菌对大黄总蒽醌和大黄酸标准品的敏感性试验。甲壳胺对口腔常见菌的凝集试验。用龋活性试验做甲壳胺对变形链球菌的解吸附试验。用钢管法做大黄滴剂对口腔常见菌的抑菌试验。结果:大黄总蒽醌和大黄酸标准品对口腔常见菌都有不同程度的抑菌作用。甲壳胺除对齿双歧外,对其他口腔常见菌均有凝集作用。甲壳胺对变形链球菌有解吸附作用。成品大黄滴剂对口腔常见菌有抑菌作用。结论:大黄滴剂有明显抑菌作用。
Objective: To develop a new effective periodontal antibacterial agent, instead of the conventional drug. Methods: Agar dilution method to do several kinds of common oral bacteria rhubarb anthraquinone and rhein standard sensitivity test. Agglutination test of chitosan against common oral bacteria. Desaturation test of Streptococcus mutans by chitosan with cariogenic activity test. Inhibitory Effect of Dahuang Drops on Oral Bacteria by Pipe Method. Results: Rheum total anthraquinone and rhein standard oral bacteria have different degrees of inhibition of the role of bacteria. In addition to chitin bovine chitin, the other common oral bacteria have agglutination. Chitosan has a desorption of Streptococcus mutans. Finished rhubarb drops on the oral bacteria have antibacterial effect. Conclusion: Rhubarb has obvious antibacterial effect.