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目的:探讨刺五加酸(AA)对小鼠急性肝损伤的保护作用。方法:将60只小鼠随机分成6组,即正常组,乙醇模型组,水飞蓟素组(100 mg.kg-1),刺五加酸高、中、低剂量组(30,10,5 mg.kg-1)。小鼠每隔12 h给药1次,连续给药3次。每次给药后1 h,除正常组外均灌胃60%乙醇(5 g.kg-1)。观察大鼠血清的生化指标和病理组织变化。结果:在AA的高、中剂量组ALT(25±6),(31±8)U.L-1,AST(157±23),(187±18)U.L-1,TNF-α(32±4.62),(41±5.3)μg.L-1以及TG(190±23),(257±23)mmol.L-1明显下降,与模型组比较有显著性差异(P<0.001),减少了肝损伤程度。结论:刺五加酸对乙醇引起的小鼠急性肝损伤具有良好的保护作用。
Objective: To investigate the protective effect of Acanthopanax (AA) on acute liver injury in mice. Methods: Sixty mice were randomly divided into six groups: normal group, ethanol model group, silymarin group (100 mg.kg-1), acicugamycin high, medium and low dose groups (30, 10, and 5 mg. kg-1). Mice were dosed once every 12 hours and administered three times in a row. One hour after each administration, 60% ethanol (5 g.kg-1) was given to the rats except the normal group. Serum biochemical markers and pathological changes were observed. RESULTS: The ALT (25 ± 6), (31 ± 8) UL-1, AST (157 ± 23), (187 ± 18) UL-1 and TNF-α (32 ± 4.62) (41 ± 5.3) μg.L-1 and TG (190 ± 23) and (257 ± 23) mmol.L-1, respectively, which were significantly lower than those in model group (P <0.001) degree. Conclusion: Acanthopanax senticosus has a good protective effect on ethanol-induced acute liver injury in mice.