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目的观察α-2b干扰素联合高三尖彬酯碱(HHT)、小剂量阿糖胞苷(Ara-c)即小剂量HA方案治疗慢性粒细胞白血病(CML)的临床疗效。方法采用交叉对比的方法,对干扰素加小剂量HA方案组(治疗组)与干扰素加服羟基脲组(对照组)定期观察缓解时间、血象、骨髓象变化。结果治疗组血液学稳定,持续缓解时间明显长于对照组,生存率亦高于对照组。结论α-2b干扰素联合小剂量HA方案是治疗CML的有效方法,值得推广应用。
Objective To observe the clinical effects of α-2b interferon combined with triclosanine (HHT) and low-dose Ara-c, a low-dose HA regimen in the treatment of chronic myelogenous leukemia (CML). Methods The cross-contrast method was used to observe the changes of remission time, hemogram and bone marrow of the HA group (treatment group) and the interferon plus hydroxyurea group (control group) on a regular basis. Results The hematology of the treatment group was stable, the duration of sustained remission was significantly longer than that of the control group, and the survival rate was also higher than that of the control group. Conclusion The combination of interferon alfa-2b and low-dose HA is an effective method for the treatment of CML, which is worthy of promotion and application.