Previous experiments with organo-metallic compounds like ferrocene,nickelocene and magnesocene showed that a pure spectrum must be obtained on the residual gas mass analyser before running successfully on the ion source.In collaboration with the chemistry department of the University of Caen,LCMT-ENSI Caen,the synthesis of these metallocene compounds has been studied to provide enriched isotopic compounds to GANIL’s users.The chemical transformation yields were 90%,80% and 43%,respectively.Vanadocene, chromocene,colbatocene and ruthenocene compounds have first been studied with a gas mass analyser and then successfully tested on the ECR 4M ion source at GANIL.Some 15eμA of ~(51)V~(11+),20eμA of ~(52)Cr~(11+), 22eμA of 59Co~(11+),and 17eμA of ~(102)Ru~(11+) were achieved.The comparison between the results obtained on the gas mass analyser and the ion beams provided by the source has allowed us to validate this method of determining whether or not an organo-metallic compound could be a candidate for running on our ECR ion source.As the ECR ion sources are tuned and used alternately on the GANIL injectors,the available time for the tests is rare,so this method could be an alternative for the validation of new compounds. Previous experiments with organo-metallic compounds like ferrocene, nickelocene and magnesocene showed that a pure spectrum must be obtained on the residual gas mass analyzer before running successfully on the ion source. In collaboration with the chemistry department of the University of Caen, LCMT-ENSI Caen, the synthesis of these metallocene compounds has been studied to provide enriched isotopic compounds to GANIL’s users. The chemical transformation yields were 90%, 80% and 43%, respectively. Vanadocene, chromocene, colbatocene and ruthenocene compounds have first been studied with a gas mass analyzer and then successfully tested on the ECR 4M ion source at GANIL.Some 15eA of ~ (51) V ~ (11+), 20eA of ~ (52) Cr ~ (11+), 22eA of 59Co ~ (11+ ) and 17eA of ~ (102) Ru ~ (11+) were obtained. The comparison between the results obtained on the gas mass analyzer and the ion beams provided by the source has allowed us to validate this method of determining whether or not an organo-metallic compound could be a candidate for running on our ECR ion source. As the ECR ion sources are tuned and used alternately on the GANIL injectors, the available time for the tests is rare, so this method could be an alternative for the validation of new compounds.