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分析运用 Weibull概率 -多元线性及三维空间立体模型预测药物稳定性的方法。以 lnln ( 1 /( 1 - F( t) ) )为 Y轴〔药物降解累积百分率 F ( t) =( c0 - c) /c0 〕,以时间 t的对数 ln( t)为 X轴 ,以绝对温度的倒数 1 /T为 Z轴的 Weibull概率的三维坐标 ,从药物平面上找出药物贮存期 ;或者以 Weibull概率公式以lnln ( 1 /( 1 - F ( t) ) )和 1 /T为变量 ,对时间的对数 ln ( t)进行多元线性回归求算。
The method of predicting drug stability by using Weibull probability-multivariate linear and three-dimensional spatial model was analyzed. Taking the lnln (1 / (1 - F (t))) as the Y axis (the cumulative percentage of drug degradation F (t) = (c0 - c) / c0), the logarithm of the time t ln (t) Find out the drug storage period from the drug plane by using the three-dimensional coordinates of the Weibull probability of the reciprocal 1 / T of absolute temperature as the Z-axis, or use lnln (1 / (1 - F (t))) and 1 / T is a variable, the logarithm of time ln (t) for multiple linear regression.