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Objective:To evaluate the efficacy and safety of Qing Dai(indigo naturalis),a traditional Chinese medicine,in the treatment for chronic hemorrhagic radiation proctitis.Methods:Ten patients with chronic hemorrhagic radiation proctitis between January 2005 to January 2008 were treated with Qing Dai.Qing Dai was administered orally at a dose of 1.5 g,bid for 5 consecutive days,every 2 weeks for two courses.Patients were followed up every 3 months.The clinical response and side-effects were evaluated.Results:Six patients showed improvement of rectal bleeding to grade 0-1 after 1 course of Qing Dai therapy.Four patients had reduced rectal bleeding to grade 0-1 after 2 courses of the therapy.The median follow-up time was 10 months(range:6-24).During the follow-up period,1 patient experienced recurrent rectal bleeding and was managed with topical formalin dabbing,which controlled the symptom.No treatment toxicity was observed.Conclusion:Qing Dai may be a safe and effective treatment for chronic hemorrhagic radiation proctitis.
Objective: To evaluate the efficacy and safety of Qing Dai (indigo naturalis), a traditional Chinese medicine, in the treatment for chronic hemorrhagic radiation proctitis. Methods: Ten patients with chronic hemorrhagic radiation proctitis between January 2005 to January 2008 were treated with Qing Dai .Qing Dai was administered orally at a dose of 1.5 g, bid for 5 consecutive days, every 2 weeks for two courses. Patients were followed up every 3 months. Clinical responses and side-effects were evaluated. Results: Six patients showed improvement of rectal bleeding to grade 0-1 after 1 course of Qing Dai therapy. Four patients had reduced rectal bleeding to grade 0-1 after 2 courses of the therapy. The median follow-up time was 10 months (range: 6-24) . During the follow-up period, 1 patient experienced recurrent rectal bleeding and was managed with topical formalin dabbing, which controlled the symptom. No treatment toxicity was observed. Conlusion: Qing Dai may be a safe and effective treatment for chron ic hemorrhagic radiation proctitis.