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没有用过水痘免疫球蛋白预防而有免疫损伤的白血病患儿,初次感染疱疹病毒发生内脏播散者占30%,此类患者中7%可能死亡。虽然抗病毒药物和水痘—带状疱疹免疫球蛋白的使用已减少了重症水痘的发病率。然而均有它们的局限性。本文叙述了44例急性原始淋巴细胞白血病(ALL)患儿在继续或暂停6—硫基嘌呤(6-MP)的缓解期接种Oka/Merck疫苗后的结果。方法用美国生产的851型Oka/Merck疫苗,每1ml冰冻疫苗约含1.4×10~3疱斑形成单位,解冻后立即皮下注射。ALL患儿在接种前至少已缓解6个月以上。接种前根据抗水痘抗体阴性来证实无既往感染水痘史,免疫期间淋巴细胞绝对数≥500/μl,并且在试
Children with leukemia who have not been immunized against chicken pox immunoglobulin have a 30% incidence of visceral sfections for initial herpes virus infection and 7% of these patients may die. Although the use of antiviral drugs and chickenpox-shingles immunoglobulins has reduced the incidence of severe chickenpox. However, both have their limitations. This article describes the results of 44 patients with acute lymphoblastic leukemia (ALL) who received the Oka / Merck vaccine while continuing or discontinuing the 6-thioguanine (6-MP) remission. Methods US-made vaccine type 851 Oka / Merck, frozen vaccine per 1ml containing about 1.4 × 10 ~ 3 blister formation unit, thawed immediately after subcutaneous injection. ALL children have been relieved for at least 6 months before vaccination. Pre-vaccination based on anti-chickenpox antibody negative to confirm no history of past infection varicella, lymphocyte absolute number during immunization ≥ 500 / μl, and in the test