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目的探讨醋酸甲地孕酮治疗子宫内膜癌对患者生活质量的影响。方法将96例子宫内膜癌患者随机分为观察组和对照组,每组各48例,观察组患者应用醋酸甲地孕酮强化治疗,对照组患者予常规化学治疗,比较两组患者的生活质量评分及胃肠道反应情况。结果观察组患者生活质量评分为(40.2±10.2)分,对照组患者为(31.2±13.5)分,两者比较差异有统计学意义(P<0.05);观察组患者生活质量优良率为45.8%(22/48),对照组患者为22.9%(11/48),两者比较差异有统计学意义(P<0.05)。观察组患者胃肠耐受良好率为47.9%(23/48),对照组患者为29.2%(14/48),两者比较差异有统计学意义(P<0.05)。结论醋酸甲地孕酮治疗是子宫内膜癌有效的辅助治疗方法,能够提高患者的生活质量,改善胃肠道耐受性,值得临床进一步研究应用。
Objective To investigate the effect of megestrol acetate on the quality of life of patients with endometrial cancer. Methods 96 patients with endometrial cancer were randomly divided into observation group and control group, 48 cases in each group. Patients in observation group were treated with megestrol acetate. Patients in control group were given routine chemotherapy. The life of patients in two groups Quality score and gastrointestinal reaction. Results The quality of life of observation group was (40.2 ± 10.2) points, while that of control group was (31.2 ± 13.5) points, the difference was statistically significant (P <0.05). The excellent and good quality of life of observation group was 45.8% (22/48) in the control group and 22.9% (11/48) in the control group. The difference between the two groups was statistically significant (P <0.05). The good rate of gastrointestinal tolerance was 47.9% (23/48) in the observation group and 29.2% (14/48) in the control group, the difference was statistically significant (P <0.05). Conclusion Megestrol acetate treatment is an effective adjuvant treatment of endometrial cancer, can improve the quality of life of patients and improve gastrointestinal tolerance, it is worth further clinical study.