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目的探讨前列地尔脂微球载体注射液对老年缺血性结肠炎患者复发的预防作用。方法将50例老年人缺血性结肠炎患者随机分为治疗组(25例)和对照组(25例),对照组采用常规治疗,治疗组在此基础上加用前列地尔脂微球载体制剂治疗。比较两组的疗效、转手术治疗率、病死率及随访1年复发率。结果治疗组显效22例,有效2例,无效1例,总有效率为96.0%;对照组显效14例,有效4例,无效7例,总有效率为72.0%,治疗组总有效率明显高于对照组(P<0.05),治疗组患者的转手术治疗率、病死率及随访1年复发率均明显低于对照组(P<0.05)。结论前列地尔脂微球载体治疗老年缺血性结肠炎患者的疗效明显,并通过抑制血栓形成、扩张血管增加血流量及降低血液粘度来预防患者复发。
Objective To investigate the preventive effect of alprostadil injection on the recurrence of senile ischemic colitis. Methods Fifty elderly patients with ischemic colitis were randomly divided into treatment group (n = 25) and control group (n = 25). The control group was treated with conventional therapy. The treatment group was treated with alprostadil Preparation treatment. The curative effect of the two groups were compared, the rate of operation and treatment, mortality and follow-up 1-year recurrence rate were compared. Results In the treatment group, 22 cases were markedly effective, 2 cases were effective, 1 case was ineffective, and the total effective rate was 96.0%. In the control group, 14 cases were markedly effective, 4 cases effective and 7 cases ineffective with a total effective rate of 72.0%. The total effective rate was significantly higher In the control group (P <0.05), the patients treated in the treatment group had a significantly lower rate of revascularization and mortality and 1-year follow-up than those in the control group (P <0.05). Conclusions Alprostadil lipid microspheres carrier is effective in the treatment of elderly patients with ischemic colitis and can prevent the recurrence of patients by inhibiting thrombosis, dilating blood vessels and increasing blood flow and lowering blood viscosity.