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目的探讨吗啡与血管平滑肌钙通道的关系；吗啡对血管平滑肌条作用的受体机制。方法用高K+、脱羟肾上腺素开放血管平滑肌钙通道及用阿片受体阻断剂纳络酮预处理血管条观察吗啡对血管条的作用。结果吗啡使60mmol／LK+、10－7mol／L脱羟肾上腺素预收缩的血管条松驰，舒张百分数分别为59．5％±2％、26．8％±0．4％；两组与生理盐水对照组相比，均有显著差异，P＜0．001。吗啡使纳络酮预孵育的经脱羟肾上腺素预收缩的血管条舒张，舒张百分数为39．7％±1．8％；与吗啡对照组相比有显著差异，P＜0．001。结论吗啡可抑制60mmol/AK+、10－7mol/L脱羟肾上腺素引起的主动脉血管平滑肌细胞膜上电位依赖及受体依赖钙通道的开放，阻止外钙内流；主动脉血管条上的吗啡效应可能不是通过经典的阿片受体。
Objective To investigate the relationship between morphine and calcium channel of vascular smooth muscle and the receptor mechanism of morphine on vascular smooth muscle strips. Methods The effect of morphine on vascular strips was observed by opening the vascular smooth muscle calcium channels with high K + and ethionine and pretreatment of vascular strips with naloxone, an opiate receptor blocker. Results Morphine relaxation of 60mmol / L K +, 10-7mol / L phenylephrine precontracted vascular strips relaxation, diastolic percentage were 59.5% ± 2%, 26.8% ± 0.4%; two groups and physiological Saline control group, there was a significant difference, P <0.001. Morphine pre-naloxone preconditioned by the hydroxynitrite precontracted vascular strips diastolic, diastolic percentage was 39.7% ± 1.8%; compared with the morphine control group were significantly different, P <0.001. Conclusion Morphine can inhibit the potential dependence of 60mmol / AK + and 10-7mol / L phenylephrine on the membrane potential of aortic vascular smooth muscle cells and the receptor-dependent calcium channel opening, and prevent the influx of extracellular calcium. Morphine effect in aortic strips Probably not through the classical opioid receptors.