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探讨力竭游泳后即刻、 2 4h、 48h大鼠大脑组织自由基代谢的动态变化 ,为力竭运动后大脑组织的恢复提供实验依据。结论 :力竭游泳可激活大鼠大脑组织抗自由基氧化酶SOD活性 ,加快脑组织自由基的清除速率 ,减少自由基代谢产物MDA的堆积 ,减弱因力竭游泳产生的自由基对脑组织细胞的损伤 ,表明大脑组织有较强的抗自由基损伤能力 ;力竭游泳引起大鼠端脑组织内GSH -px活性下降 ,表明力竭游泳使大脑组织细胞磷酸戊糖代谢途径加快 ,NADPH消耗量增加 ,同时GSH -px参与清除自由基过程而引起GSH -px活性下降。力竭运动后不同时段的恢复期MDA和SOD指标可作为评价力竭运动对机体组织影响的参考依据。
To explore the dynamic changes of free radical metabolism in the brain tissue of rats after 24 hours and 48 hours after exhaustive swimming, and to provide an experimental basis for the recovery of brain tissue after exhaustive exercise. Conclusion: Exhausted swimming can activate the activity of free radical oxidase SOD in brain tissue of rats, accelerate the clearance rate of free radicals in brain tissue, decrease the accumulation of free radical metabolite MDA and weaken the effect of free radicals produced by exhaustive swimming on brain cells , Indicating that brain tissue has a strong anti-free radical damage ability; exhaustive swimming caused a decrease in GSH-pX activity in rat telencephalon, suggesting that exhaustive swimming accelerated the metabolism of pentose phosphate in brain cells, and NADPH consumption Increase, while GSH-pX involved in the process of scavenging free radicals caused GSH-px activity decreased. After exhaustive exercise in different periods of recovery of MDA and SOD indicators can be used as a reference to evaluate the impact of exhausting exercise on the body tissue.