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目的观察暴露后人群接种国产人用狂犬病无佐剂纯化疫苗(Vero cell)的免疫效果。方法对53例研究对象按照0、3、7、14和28 d程序进行暴露后免疫,采用WHO认可的RFFIT法检测免疫14 d,45 d的血清抗体。观察每针次接种后72 h内局部和全身反应。结果所有接种对象均未出现严重副反应。首剂免疫14 d,45 d ELISA法检测抗体阳性率分别为52.83%,94.34%,RFFIT法检测抗体阳性率分别为100%,100%。几何平均滴度(GMT)为17.74 IU/ml,15.50 IU/ml。结论国产人用狂犬病无佐剂纯化疫苗(Vero cell)具有良好的安全性和免疫原性。
Objective To observe the immune effect of vaccinated domestic rabies vaccinated non-adjuvanted purified vaccine (Vero cell) after exposure. Methods Fifty-three subjects were immunized after 0, 3, 7, 14 and 28 days of exposure. Serum antibodies of 14 days and 45 days after immunization were detected by WHO-approved RFFIT. Local and systemic responses were observed within 72 h after each needle inoculation. Results All inoculated subjects did not appear serious side effects. The first immunization 14 d, 45 d ELISA positive rates were 52.83%, 94.34%, RFFIT positive rates were 100%, 100%. The geometric mean titers (GMTs) were 17.74 IU / ml and 15.50 IU / ml. Conclusion The domestic rabies vaccine without human adjuvant (Vero cell) has good safety and immunogenicity.