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Purpose: To analyze the hereditary modality of primary open-angle glaucoma in China. Methods: The genetic form of Pedigree GZ. 1 was analyzed using Mandalian hereditary rules.Results: Pedigree GZ. 1 had following characteristics: 1) The pedigree had four generations, and there existed POAG patients in each generation; 2) Each patient had a parent with POAG. If the parents didn’t suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1/2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients.Conclusions: 1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients. Eye Science 2000; 16: 53 - 55.
1: analyzed the hereditary modality of primary open-angle glaucoma in China. Methods: The genetic form of Pedigree GZ. 1 was used using Mandalian hereditary rules. Results: Pedigree GZ. 1 had the following characteristics: 1) The pedigree had four generations If the parents did not suffer from the disease, their children would not. 3) The incidence of POAG in the relatives of the patients was 1 / 2. In addition, The age of onset, intraocular pressure, fundus and prognosis was different from each other in the patients. Conclusions: 1) Pedigree GZ. 1 is inherited as an autosomal dominant trait. 2) There exists individual differences of clinical manifestations in POAG patients. Eye Science 2000; 16: 53-55.