论文部分内容阅读
目的 为合理利用流行性乙型脑炎 (乙脑 )灭活疫苗和减毒活疫苗各自的优点 ,降低预防接种反应的发生率 ,提高免疫学效果 ,开展了乙脑灭活疫苗与减毒活疫苗相结合的免疫策略研究。方法 观察比较两种疫苗单一使用与联合使用的免疫学效果及安全性。结果 联合使用组在疫苗接种后 2 4h的全身中强以上发热反应发生率为 0 .73 % ,局部红晕反应为 1 .46 % ,而单一使用灭活疫苗组的发热反应发生率为 2 .8%。不同观察组疫苗接种后中和抗体几何平均滴度由免疫前的 1∶1 .0 5～1∶3 .35上升至 1∶47.34～ 1∶1 0 1 .30 ,联合使用组的中和抗体阳转率为 97.67% ,明显高于单一使用灭活疫苗组 86 .2 7%的阳转率 (χ2 =3 .89,P <0 .0 5) ,但与单一使用减毒活疫苗组 93 .75 %的阳转率差异无显著性 (χ2 =0 .74,P >0 .0 5)。结论 研究表明对婴幼儿使用乙脑灭活疫苗基础免疫、减毒活疫苗加强免疫有很好的免疫学效果及安全性 ,也是切实可行和比较理想的免疫策略
The purpose of rational use of Japanese encephalitis (JE) inactivated vaccine and live attenuated attenuated vaccine each advantage, reduce the incidence of vaccination response and improve the immunological effect, launched a JE inactivated vaccine and attenuated live Vaccine combined immunization strategy research. Methods The immunological effects and safety of single and combined use of two vaccines were compared. Results The combined incidence of moderate to severe general fever was 0.73% and the local flushing reaction was 1.46% in the combination group at 24 hours after vaccination, while the incidence of fever in the single-use inactivated vaccine group was 2.8 %. The geometric mean titers of neutralizing antibodies after vaccination in different observation groups increased from 1: 1.05 ~ 1: 3.35 before immunization to 1: 47.34 ~ 1: 1: 0.30, and the combined use of neutralizing antibodies The rate of positive conversion was 97.67%, which was significantly higher than that of 86.27% (χ2 = 3.89, P <0.05) in single inactivated vaccine group. However, .75% positive rate was no significant difference (χ2 = 0.74, P> 0.05). Conclusions Studies have shown that immunization of infants and young children with basic inactivated JE vaccine, live attenuated vaccine has good immunological effects and safety, but also feasible and ideal immunization strategy