硼中子捕获治疗(boron neutron capture therapy,BNCT)是利用10B(n,α)7Li反应产生的高能α粒子和反冲7Li原子进行治疗的高传能线密度辐射治疗方式,含硼化合物是硼中子捕获治疗的重要方面,其中含硼卟啉是上世纪90年代起广受关注的含硼化合物。介绍了硼中子捕获治疗及含硼卟啉的特点,阐述了近20年来的研究进展,为设计高效含硼卟啉衍生物提供参考。 Boron neutron capture therapy (boron neutron capture therapy, BNCT) is the use of high energy alpha particles produced by 10B (n, α) 7Li reaction and recoil 7Li atomic radiation treatment for high energy radiation density, boron-containing compounds is boron Among the important aspects of neutron capture therapy, boron-containing porphyrins are the most popular boron-containing compounds since the 1990s. The characteristics of boron neutron capture therapy and boron-containing porphyrin were introduced. The research progress in the past two decades was expounded, which provided a reference for the design of highly efficient porphyrin-containing porphyrin derivatives.