个体的发育除受内部基因调控外 ,还受外部环境的影响。环境中存在的许多因素都具有胚胎毒性及致畸性 ,如农业上使用的杀虫剂、农药 ,工业生产排放的毒物以及高温等。本文仅就汞、硒、砷的胚胎毒性和致畸性及其作用机制作一综述 ,其作用机制重点集中在对胚胎细胞凋亡和 或增殖的影响。 In addition to the individual’s development of internal gene regulation, but also affected by the external environment. Many of the factors that exist in the environment are embryotoxic and teratogenic, such as pesticides used in agriculture, pesticides, toxic emissions from industrial processes, and high temperatures. This article reviews the embryotoxicity and teratogenicity of mercury, selenium and arsenic and their mechanism of action. The mechanism of action focuses on the apoptosis and / or proliferation of embryonic cells.