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作者对351名30～69岁的丹麦人进行了研究,了解其白喉类毒素的接种史,采血,用Vero细胞组织培养中和法测定血中白喉抗体浓度,0.01IU/ml为保护水平。90人抗体浓度低于0.01IU/ml,55人略高于保护水平(0.01～0.05IU/ml)。将其中126人随机分成3组,分别皮下接种2个絮状反应单位(Lf)、5Lf和12Lf白喉类毒素,每ml制剂中含1ing Al(OH)_3作为佐剂。接种后4周,采集123人的血液,并观察到反应。20人有接种卡证明,他们曾于23～41年前接受了白喉类毒素全程基础免疫,34人口述于28～43年前接受过抗白喉免疫,39人未曾接种,
The author of 351 Danish people aged 30 to 69 were studied to understand the history of diphtheria toxoid vaccination, blood collection, with Vero cell culture neutralizing method for the determination of blood diphtheria antibody concentration, 0.01IU / ml for the protection level. 90 human antibody concentrations below 0.01 IU / ml, 55 slightly higher than the level of protection (0.01 ~ 0.05IU / ml). One hundred and sixty-six of them were randomly divided into three groups and inoculated subcutaneously with two flocculent reaction units (Lf), 5Lf and 12Lf of diphtheria toxoid, each containing 1 ing Al (OH) 3 adjuvant. Four weeks after inoculation, 123 human blood was collected and the reaction was observed. Twenty people had a vaccination card to prove that they had undergone the entire primary diphtheria toxoid-based immunization 23 to 41 years ago, 34 had oral anti-diphtheria immunizations 28 to 43 years ago, 39 had not been vaccinated,