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有人曾称,世界新药的推陈出新以四十至六十年代为黄金时代。在此期间,抗生素类和其它抗感染药、抗组胺类药物、神经精神系统药物、Alpha 和 Beta-肾上腺素能受体阻断剂之用于心血管疾病、抗肿瘤药物、强效麻醉镇痛药、口服避孕药和多种甾族激素衍生物的开发、合成抗糖尿病药物、利尿降压药、Beta-内酰胺类半合抗的合成、抗病毒药、喹酮酸类杀菌剂的发现、抗血管硬化和溶血栓物质的发现等相继出现。但是到了七十年代,由于以下两个原因,新药上市的速度显著减慢,研究与开发的费用急
Someone once said that the emergence of new drugs in the world took the golden age from the forties to the sixties. During this period, antibiotics and other anti-infectives, antihistamines, neuropsychiatric drugs, Alpha and Beta- adrenergic receptor blockers for cardiovascular diseases, antineoplastic agents, potent narcotic Development of painkillers, oral contraceptives and derivatives of various steroidal hormones, synthesis of antidiabetic drugs, diuretic antihypertensive drugs, synthesis of Beta- lactam semisynthetic agents, antiviral drugs, and the discovery of quorcetionic bactericides , Anti-vascular sclerosis and thrombolytic substances found one after another. However, by the seventies, due to the following two reasons, the speed of listing new drugs significantly slowed down, and the cost of research and development