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目的：探讨荔枝核总黄酮（TFL）对小鼠急性肺损伤的影响及作用机制。方法：将60只 C57BL/6小鼠随机分成正常组、模型组、地塞米松组（3 mg.kg-1）、荔枝核总黄酮100 mg.kg-1、50 mg.kg-1、25 mg.kg-1剂量组，每组10只。连续灌胃给药7 d，空白组和模型组给予等体积的生理盐水。末次给药30 min 后，腹腔注射20%酵母混悬液（5 mL.kg-1）建立小鼠急性肺损伤模型。末次给药24 h 后，处死小鼠，摘眼球取血，分离血清，待测。对小鼠肺组织进行的湿干比重(W/D)测定。ELISA 法检测血清中肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、白介素-10（IL-10）、细胞间黏附分子-1（ICAM-1）的含量。检测大鼠肺组织中超氧化物歧化酶(SOD)和丙二醛(MDA)的含量及髓过氧化物酶(MPO)的活性。结果：与模型组相比，荔枝核总黄酮治疗组的小鼠肺组织湿干比重降低， TNF-α、IL-6、ICAM-1及 MDA 的含量下降，MPO 的活性降低，SOD、IL-10的含量增加（P<0.05）。结论：提前给予荔枝核总黄酮可明显下降炎症因子的含量，缓解炎症反应，同时发挥其抗氧化应激的作用，达到保护肺组织的作用。“,”Objective To investigate the protective effect of puerarin on acute lung injury. Methods Sixty C57BL/6 mice were randomly divided into normal group, model group, dexamethasone group (3 mg.kg-1), 100, 50, 25 mg.kg-1 of TFL groups with 10 rats respectively. Mice were intragastric gavagedfor 7 days. Normal groupand model group were given saline. Thirty minutes after last yeast suspension every 12h for two times. The wet and dry proportion, SOD, MDA and MPO in lung tissue were determined. Serum TNF-α, IL-6, IL-10, ICAM-1 contents were detected withELISA method. Results Comparedwith model group, wet and dry proportion of lung tissue,TNF-α, IL-6,ICAM-1, MPO and MDAcontents were decreased by TFL, SOD, IL-10 content increased (P<0.05). Conclusion The TFL can significantly decrease the content of inflammatory factors, relieve the inflammatory reaction, and play the role of anti oxidative stress, and protect the lung tissue.