论文部分内容阅读
异构前列腺素是花生四烯酸的过氧化产物,组织产生后进入循环血液,经肾脏由尿中原形排出,在血液或尿液中能存留较长时间,不受体外氧化物质的影响而能较准确地反映体内氧化应激水平。其与血栓素受体:血栓素A2/前列腺素H2(TP)类似物结合引起血管平滑肌收缩、血小板激活等生物效应,在临床氧化应激性疾病的发生发展中起了重要的作用。而适当的生活方式或予以抗氧化物质能显著减少异构前列腺素的产生和相关疾病的发生。
Heterotrophs prostaglandin is a product of arachidonic acid peroxidation, the organization into the circulating blood generated by the urine of the prototype excreted in the blood or urine can survive for a long time, not subject to the impact of oxidizing substances in vitro Can more accurately reflect the level of oxidative stress in vivo. Its binding to thromboxane A2 / prostaglandin H2 (TP) analogues leads to the biological effects of vascular smooth muscle contraction and platelet activation, and plays an important role in the development of clinical oxidative stress diseases. Proper lifestyle or anti-oxidant substances can significantly reduce the incidence of heterogeneous prostaglandins and related diseases.