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目的探讨总前列腺特异性抗原(PSA)与游离前列腺特异性抗原(fPSA)比值(f/t)在PSA为4-10ng/ml时对前列腺癌诊断的意义。方法回顾行分析血清tPSA为4-10ng/ml的前列腺癌和前列腺增生83例患者。前列腺癌与前列腺增生组间采用t检验。血清中fPSA与tPSA测定通过酶免微粒子捕捉法测定。均前列腺穿刺组织学验证。结果本组中51例为前列腺增生(62%),32例为前列腺癌(38%)。前列腺癌及前列腺增生组f/t平均值分别为0.16和0.23,tPSA的平均值分别为6.63ng/ml和6.99ng/ml;两组之间tPSA、fPSA无显著行差异(P>0.05);当f/tPSA比值以0.16作为临界值时,其敏感性及特异性分别为71%、78%,有着较高的准确率率。但前列腺癌患者f/t值明显低于前列腺增生患者(P<0.01)。结论以0.16作为f/t临界值在灰区内对前列腺癌及前列腺增生的鉴别起到重要意义,可以有较高的准确率。
Objective To investigate the significance of the ratio of total prostate-specific antigen (PSA) to free prostate-specific antigen (fPSA) in the diagnosis of prostate cancer when PSA is 4-10ng / ml. Methods Retrospective analysis of serum tPSA 4-10ng / ml of prostate cancer and benign prostatic hyperplasia in 83 patients. Prostate cancer and benign prostatic hyperplasia group using t test. Determination of serum fPSA and tPSA enzyme particle capture method. All prostate biopsy histological verification. Results 51 cases of benign prostatic hyperplasia (62%), 32 cases of prostate cancer (38%). The mean f / t values for prostate cancer and benign prostatic hyperplasia were 0.16 and 0.23, respectively. The mean values of tPSA were 6.63ng / ml and 6.99ng / ml, respectively. There was no significant difference in tPSA and fPSA between the two groups (P> 0.05). When the f / tPSA ratio of 0.16 as the critical value, the sensitivity and specificity were 71%, 78%, with a high accuracy rate. However, the f / t value of prostate cancer patients was significantly lower than that of benign prostatic hyperplasia patients (P <0.01). Conclusion 0.16 as the f / t critical value in the gray zone of prostate cancer and benign prostatic hyperplasia of great significance, can have a high accuracy.