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癌胚抗原(CEA)1965年首先由Gold和Freeman发现,它是一种细胞表面的糖蛋白,由胎儿的肠管、肝和脾分离出来。胎儿生长到6个月后,CEA即从血循环中消失。临床上CEA检查对结直肠癌的诊断颇有帮助,如术前患者CEA水平升高,往往说明病情较晚预后不良。约80％的患者在临床上尚未见癌症复发前CEA值即呈现上升。肿瘤手术以后,CEA水平可作为很有帮助的病情监测标记,
Carcinoembryonic antigen (CEA) was first discovered by Gold and Freeman in 1965. It is a cell surface glycoprotein that is separated from the fetal intestine, liver, and spleen. After the fetus has grown to 6 months, CEA disappears from the blood circulation. Clinical CEA examination is helpful for the diagnosis of colorectal cancer. If the preoperative level of CEA is elevated, it often indicates that the condition is late and the prognosis is poor. About 80% of patients had no clinically seen increase in CEA before cancer recurrence. After oncological surgery, CEA levels can be helpful markers for disease monitoring.