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目的:探讨喜脑宁对脑缺血再灌注损伤的保护作用及其机制。方法:采用大鼠线栓法制备脑缺血再灌注模型,观察喜脑宁对神经功能评分、脑梗死体积和脑组织病理形态学变化的影响,电镜观察脑组织超微结构,免疫组化检测肿瘤坏死因子-α的表达。结果:喜脑宁(12,24g.kg-1)可降低脑缺血再灌注后的神经功能评分和脑梗死体积,改善脑组织病理形态学和超微结构,抑制脑组织肿瘤坏死因子-α的表达。结论:喜脑宁对脑缺血再灌注损伤具有一定的保护作用,其机制可能与抑制肿瘤坏死因子α的表达有关。
Objective: To explore the protective effect and its mechanism of “Xinaoning” against cerebral ischemia-reperfusion injury. Methods: The rat model of cerebral ischemia-reperfusion was established by the method of thread plug. The neurological function score, the volume of cerebral infarction and pathomorphological changes of brain were observed. The ultrastructure of brain tissue was observed by electron microscope, immunohistochemistry Tumor necrosis factor-alpha expression. Results: Xinaoning (12,24g.kg-1) can reduce neurological deficits and cerebral infarction volume after cerebral ischemia-reperfusion, improve brain histopathology and ultrastructure, inhibit brain tumor necrosis factor-α expression. Conclusion: Xinaoning has a protective effect on cerebral ischemia-reperfusion injury, and its mechanism may be related to inhibiting the expression of tumor necrosis factor-α.