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为探讨一氧化氮（ＮＯ）的前体Ｌ－精氨酸（Ｌ－Ａｒｇ）和ＮＯ合成酶抑制剂Ｌ－硝基－精氨酸甲酯（Ｌ－ＮＡＭＥ）对围产期窒息新生大鼠血浆内皮素（ＥＴ）的影响，采用放射免疫分析法检测窒息新生大鼠及窒息前应有Ｌ－Ａｒｇ或Ｌ－ＮＡＭＥ预处理的新生鼠血浆ＥＴ的水平。结果显示：窒息组血浆ＥＴ水平较对照组明显升高（Ｐ＜０．０１）；Ｌ－Ａｒｇ组血浆ＥＴ水平较窒息组明显下降（Ｐ＜０．０１），与对照组相比无显著差异（Ｐ＞０．０５）；而Ｌ－ＮＡＭＥ组血浆ＥＴ水平明显高于对照组及Ｌ－Ａｒｇ组（Ｐ＜０．０１），与窒息组比较，无统计学意义。提示：Ｌ－Ａｒｇ能有效地降低窒息新生大鼠血浆ＥＴ的水平；Ｌ—ＮＡＭＥ则作用相反，ＮＯ合成抑制可明显增加ＥＴ水平。
To investigate the effects of L-arginine (L-Arg), a precursor of nitric oxide (NO), and L-NAME, an NO synthase inhibitor, on perinatal asphyxia neonatal rats Plasma endothelin (ET) was measured by radioimmunoassay in neonatal rats with asphyxia and neonatal rats pretreated with either L-Arg or L-NAME. The levels of plasma ET in asphyxia group were significantly higher than those in control group (P <0.01). The levels of plasma ET in L-Arg group were significantly lower than those in asphyxia group (P <0.01), but no significant difference compared with control group (P> 0.05). However, the plasma ET level in L-NAME group was significantly higher than that in control group and L-Arg group (P <0.01), but not in asphyxia group. It is suggested that L-Arg can effectively reduce the level of plasma ET in neonatal rats with asphyxia; while L-NAME has the opposite effect, inhibition of NO synthesis can significantly increase the level of ET.