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糖皮质类固醇是效力最强的抗炎症药物。He-nch等人1949年证实了此药对类风湿关节炎病人的疗效。但其频发的副作用削减了人们对它的热情。为根除不良作用,而发展了合成药物。但效果不大。60年代末始用了一种类固醇给药方法,短期静脉“脉冲式给药”。既保留了其良好疗效,又无每日给药所带来的危险。本文总结了近年来叙述用类固醇以脉冲式给药方法治疗类风湿关节的文献,介绍了该疗法对免疫系统的作用与潜在的副作用以及推荐用此法治疗类风湿关节炎等问题。
Glucocorticosteroids are the most potent anti-inflammatory drugs. He-nch et al. Confirmed the efficacy of this drug in patients with rheumatoid arthritis in 1949. But its frequent side effects cut people’s enthusiasm for it. In order to eradicate the adverse effects, and the development of synthetic drugs. But little effect. The beginning of the 1960s used a method of steroid administration, short-term intravenous “pulsed.” Not only retains its good curative effect, but also without the dangers of daily administration. This article summarizes the recent literature describing the treatment of rheumatoid arthritis with a pulsatile administration of steroids, describes the effects and potential side effects of the therapy on the immune system, and recommends the use of this approach in the treatment of rheumatoid arthritis.