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EB 病毒由 Epsten 等(1964年)从 Burk-itt 氏淋巴瘤中检测出来的,是一种致癌性疱疹病毒,属 DNA 肿瘤病毒范畴。它除引起传染性单核细胞增多症外,尚与人类 Burkitt 氏淋巴瘤、鼻咽癌(NPC)、及弥漫性多克隆 B-细胞淋巴瘤有密切的病因学关系。但是,由于EB 病毒感染 B 细胞的宿主范围较窄,仅限于人和部分美洲猴;同时 EB 病毒的复制受到 B细胞容许性(permissivity)的限制。所以长期以来对 EB 病毒作用的遗传学研究进展缓慢,随着 DNA 重组技术及基因转移方法的广泛应用,这些限制被克服,人们对 EB 病毒基
The Epstein-Barr virus, Epstein et al. (1964), detected from Burk-itt’s lymphoma is a type of oncogenic herpesvirus that belongs to the category of DNA oncology virus. In addition to causing infectious mononucleosis, it is closely related to human Burkitt’s lymphoma, nasopharyngeal carcinoma (NPC), and diffuse polyclonal B-cell lymphomas. However, due to the narrow host range of Epstein-Barr virus-infected B cells, only humans and parts of the monkeys are restricted; at the same time, EB virus replication is limited by the B cell permissivity. So for a long time the role of Epstein-Barr virus genetic research has progressed slowly, with the DNA recombinant technology and gene transfer methods are widely used, these restrictions have been overcome, people EB virus-based