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目的探讨胃癌患者血清中细胞角蛋白-18(CK-18)、糖链抗原72-4(CA72-4)和癌胚抗原(CEA)水平及其临床意义。方法随机选取2015年5月到2016年5月常州市金坛区人民医院行胃癌治疗的患者40例作为实验组,所有病例经诊断均未患其他恶性肿瘤(肿瘤位于胃部15例,位于胃窦部9例,位于贲门胃底部16例;另外在门诊随机选取30例健康体检者作为对照组。测定两组人群血清中CK-18、CA72-4和CEA的水平。结果实验组血清中CK-18、CA72-4和CEA阳性表达与胃癌的生物学特征如年龄、性别、肿瘤位置及其大小、淋巴结转移等差异无统计学意义(P>0.05);实验组CK-18、CEA、CA74-2浓度(中位数)分别为2.03、2.93、4.34 ng/ml,均显著低于对照组的8.96、8.35、21.68 ng/ml,差异有统计学意义(P<0.05)。结论 CK-18、CA72-4和CEA三种肿瘤指标联合检测可考虑作为新的胃癌检测指标,对胃癌预防及治疗有一定意义。
Objective To investigate the serum levels of cytokeratin-18 (CK-18), carbohydrate antigen 72-4 (CA72-4) and carcinoembryonic antigen (CEA) in patients with gastric cancer and their clinical significance. Methods Forty patients with gastric cancer treated at Changzhou Jintan District People’s Hospital were randomly selected from May 2015 to May 2016. All the cases were diagnosed without other malignancies (tumor located in the stomach of 15 cases, located in the stomach Sinus in 9 cases, located in the bottom of the cardia of the stomach in 16 cases; in addition, 30 cases of healthy subjects were randomly selected as a control group in the outpatient.Serum levels of CK-18, CA72-4 and CEA were measured.Results Serum The positive expression of CK-18, CA72-4 and CEA were not associated with the biological characteristics of gastric cancer such as age, sex, tumor location and size, lymph node metastasis, etc. There was no significant difference in CK-18, CEA, The median concentrations of CA74-2 were 2.03, 2.93 and 4.34 ng / ml, respectively, which were significantly lower than those of the control group (8.96, 8.35 and 21.68 ng / ml, respectively) 18, CA72-4 and CEA joint detection of three tumor indicators can be considered as a new indicator of gastric cancer, prevention and treatment of gastric cancer has some significance.