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目的 观察清热解毒汤治疗血热型寻常性银屑病的临床疗效,探讨其对血清TNF-α的影响情况.方法 将入选的60例患者随机分成两组,全部患者予外用维A酸哈西奈德乳膏,2次/d;治疗组(30例)同时予口服清热解毒汤,2次/d,所有患者的疗程均为4周.采用PASI评分评价治疗前后的临床疗效,酶联免疫吸附试验(ELISA)法检测治疗前后血清TNF-α水平.结果 治疗结束后,治疗组有效率(80.0％)明显高于对照组有效率(30％),治疗组PASI评分和血清TNF-α水平均较其治疗前明显降低,且治疗组PASI评分(3.80±1.47)明显低于对照组PASI评分(9.62±1.97),以上差异均有统计学意义(P均＜0.05).结论 清热解毒汤治疗血热型寻常性银屑病疗效显著,可能通过降低患者血清TNF-α水平发挥治疗作用.“,”Objective To observe the clinical efficacy of QingReJieDu decoction in the treatment of psoriasis vulgaris patients with the pattern of blood-heat and the influence on level of TNF-α in the serum.Methods All selected 60 patients were randomly divided into two groups.All patients were given topical tretinoin/halcinonide cream (twice a day).Treatment group (30 cases) was treated with QingReJieDu decoction by oral administration (twice a day) at the same time.All groups were treated for 4 weeks.The clinical efficacy was evaluated by PASI score before and after treatment.Meanwhile,levels of TNF-α in serum were detected by enzyme linked immunosorbent assay ELISA.Results After treatment,the effective rate of the treatment group (80.0％) was significantly higher than that of the control group (30％);the PASI score and the level of TNF-α in the serum of treatment group were significantly decreased;and the PASI score of the treatment group (3.80 ± 1.47)was significantly lower than that of the control group (9.62 ± 1.97).All of these differences were statistically significant compared with control group (P ＜ 0.05).Conclusion QingReJieDu decoction in the treatment of psoriasis vulgaris patients with the pattern of blood-heat is effective,possibly by reducing expression level of TNF-α in the serum.