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目的了解延安市健康人群麻疹免疫状况,有针对性地开展麻疹疫苗的预防接种。方法随机抽样确定宝塔区、志丹县健康人群506名,分为<1岁、1～2岁、3～4岁、5～6岁、7～14岁、15～19岁、≥20岁7个年龄组,每组随机抽取不少于50人,采集血清;用ELISA法检测人群血清中麻疹IgG抗体水平。结果人群麻疹IgG抗体GMT为1∶611.89,阳性率77.27%,<1岁最低,GMT为1∶181.16,阳性率44%,1～2岁较高,GMT为1∶910.10,阳性率81.13%,1～6岁随着年龄的增长GMT和阳性率呈下降趋势,7岁以上GMT和阳性率明显增高。结论延安市健康人群的麻疹IgG抗体水平比较高;6岁以前随着年龄的增长,易感人群有增加趋势,局部仍有麻疹暴发的可能,关注6岁儿童特别是流动儿童的麻疹疫苗接种工作,必要时开展麻疹疫苗强化免疫。
Objective To understand the immune status of measles in healthy population in Yan’an City and to carry out measles vaccination in a targeted manner. Methods A total of 506 healthy people in Baota District and Zhidan County were randomly selected and divided into three groups: <1 year old, 1 ~ 2 years old, 3 ~ 4 years old, 5 ~ 6 years old, 7 ~ 14 years old, 15 ~ 19 years old, ≥ 20 years old 7 One age group, each group were randomly selected not less than 50 people, serum was collected; serum anti-measles IgG antibody levels were detected by ELISA. Results The GMT of measles IgG was 1: 611.89, the positive rate was 77.27%, the lowest was <1 year old, the GMT was 1:181.16, the positive rate was 44%, the higher was 1 to 2 years old, the GMT was 1: 910.10, the positive rate was 81.13% 1 to 6 years old With the increase of age GMT and the positive rate showed a downward trend, GMT and the positive rate was significantly higher than 7 years of age. Conclusion Measles IgG antibody levels are relatively high in healthy population in Yan’an City. Before age 6, the susceptible population tends to increase with the increase of age, and the outbreak of measles is still possible in some areas. The measles vaccination work of 6-year-old children, especially migrant children is concerned , If necessary, to carry out measles vaccine to strengthen immunity.