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对白细胞介素-6的研究始于80年代初,人们发现激活的T细胞可分泌多种B细胞因子,促进B细胞增殖和分泌抗体,故称B细胞刺激因子2(B-cell Stimulat-ing Factor-2,BSF-2)/B用细胞终末分化因子(B-cell Differentiation Factor,BCDF).根据其组织来源和作用特性的多样性,曾给予了不同的名称经分子克隆研究证实它们是同一种蛋白分子,命名为白细胞介素-6(Interleukin-6,IL-6).本文对IL-6的抗肿瘤作用,机制及生物治疗方面的进展加以综述.1 IL-6抗肿瘤作用及机制IL-6是一个多功能细胞因子,在宿主防御反应中
The study of interleukin-6 began in the early 1980s. It was found that activated T cells can secrete various B-cell factors, promote B-cell proliferation and secrete antibodies, so called B-cell Stimulat-ing. Factor-2, BSF-2)/B use the B-cell Differentiation Factor (BCDF). According to the diversity of their tissue sources and functional properties, they were given different names. Molecular cloning studies have confirmed that they are The same protein molecule is named Interleukin-6 (IL-6). This article reviews the progress of anti-tumor effects, mechanism and biological treatment of IL-6. 1 IL-6 antitumor effect and Mechanism IL-6 is a multifunctional cytokine that is in the host defense response