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目的:通过对嘉兴地区新发现的155例HIV-1抗体阳性的感染者,进行首次的CD4+ T淋巴细胞绝对值等的测定,来了解并估计其的免疫状况及疾病的进展状况。方法:对采集的155份全血样本以四色荧光抗体进行标记,通过流式细胞仪进行CD4+和CD8+ T淋巴细胞绝对值的检测,并计算CD4+/CD8+的比值。统计分析其测定值。结果:嘉兴市能随访到的HIV阳性感染者并完成CD4+ T检测的共计155例,其中CD4+ T淋巴细胞平均为296.68±212.88个/μl,CD4+/CD8+比值平均为0.37±0.24,已有36.8%HIV感染者CD4+ T<200个/μl,CD4+/CD8+<1的占98.1%;不同性别和3种传播途径的CD4+ T淋巴细胞和CD4+/CD8+比值,在结果上无显著性差异;2个年龄组间CD4+ T淋巴细胞有显著性差异,高年龄组的数值要低于低年龄组的。结论:嘉兴市有1/3新发现的HIV感染者已进入艾滋病期,应对其定期检测,估计疾病进展和及时药物治疗;同时要进行更多的艾滋病防治宣传,鼓励更多高危人群进行相关HIV抗体和CD4+ T淋巴细胞的检测,以把握治疗的最佳时期。
OBJECTIVE: To determine the first immunization of HIV-1-positive HIV-1 patients in Jiaxing and determine their absolute immune status and disease progression. Methods: The collected 155 blood samples were labeled with four - color fluorescent antibody, and the absolute value of CD4 + and CD8 + T lymphocytes was detected by flow cytometry and the ratio of CD4 + / CD8 + was calculated. Statistical analysis of the measured value. Results: A total of 155 HIV-positive patients were followed up in Jiaxing city. CD4 + T lymphocyte count was 296.68 ± 212.88 / μl, CD4 + / CD8 + ratio was 0.37 ± 0.24, 36.8% CD4 + T <200 / μl, CD4 + / CD8 + <1 accounted for 98.1% in HIV-infected patients; there was no significant difference in CD4 + T lymphocyte and CD4 + / CD8 + ratio between different sexes and three routes of transmission; CD4 + T lymphocytes were significantly different between groups, high-age group of values lower than the lower age group. Conclusion: One third of the newly discovered HIV-infected persons in Jiaxing City have entered the AIDS phase, and should be regularly tested to estimate the progress of the disease and timely drug treatment. At the same time, more HIV / AIDS prevention and treatment campaigns should be conducted to encourage more people at high risk of HIV Detection of antibodies and CD4 + T lymphocytes in order to grasp the best period of treatment.