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AIM:To evaluate whether adding azithromycin to firstline Helicobacter pylori(H pylori)eradication improved eradication and reduced side effects.METHODS:Eligible articles were identified by searches of electronic databases.We included all randomized trials that compared azithromycin-containing with standard triple-therapy regimens for first-line treatment of H pylori infection.Statistical analysis was performed with Review Manager 5.0.10.Sub-analyses were also performed.RESULTS:We identified 14 randomized trials(1431 patients).Pooled H pylori eradication rates were 72.01%(95%CI:58.09%-85.93%)and 69.78%(95% CI:66.47%-73.09%)for patients with or without azithromycin by intention-to-treat analysis,and the odds ratio(OR)was 1.17(95%CI:0.64-2.14).The occurrence of side effects differed significantly and was 15.81%(95%CI:12.50%-19.12%)and 25.20%(95%CI:21.44%-28.96%)for treatment with or without azithromycin,respectively,and the summary OR was 0.58(95%CI:0.41-0.82).Furthermore,the azithromycin-containing group had a lower occurrence of diarrhea,nausea and taste disturbance.CONCLUSION:Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of H pylori compared with standard first-line triple-therapy regimens.
AIM: To evaluate whether adding azithromycin to firstline Helicobacter pylori (H pylori) eradication improved eradication and reduced side effects. METHODS: Eligible articles were identified by searches of electronic databases. We include all randomized trials that were azithromycin-containing with triple-therapy The regimens for first-line treatment of H pylori infection. Statistical analysis was performed with Review Manager 5.0.10. Sub-analyses were also performed .RESULTS: We identified 14 randomized trials (1431 patients). Pooled H pylori eradication rates were 72.01% ( 95% CI: 58.09% -85.93%) and 69.78% (95% CI: 66.47% -73.09%) for patients with or without azithromycin by intention-to-treat analysis, and the odds ratio CI: 0.64-2.14). The occurrence of side effects differed significantly and was 15.81% (95% CI: 12.50% -19.12%) and 25.20% (95% CI: 21.44% -28.96%) for treatment with or without azithromycin, respectively, and the summary OR was 0.58 (95% CI: 0.41-0.82) .Furthermore, the azithromycin -containing group had a lower occurrence of diarrhea, nausea and taste disturbance. CONCLUSION: Our review suggests that azithromycincontaining triple-therapy regimens could be equally effective in eradication of H pylori compared with standard first-line triple-therapy regimens.