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目的:探讨在绒毛膜羊膜炎患者的羊水与胎盘中EGFR的表达情况及其相互关系。方法:通过免疫组织化学方法及采用酶联免疫吸附试验(ELISA)测定各组患者EGFR的表达情况。结果:①绒毛膜羊膜炎患者各组的EGFR表达强度较对照组明显增强。羊水粪染组与对照组比较,EGFR值升高。②绒毛膜羊膜炎组孕妇羊水中EGFR水平与胎盘组织中EGFR蛋白表达水平呈正相关关系(r=0.57,P<0.05)。结论:绒毛膜羊膜炎患者的羊水与胎盘中EGFR的表达异常,可能在绒毛膜羊膜炎发生机制中起重要作用。
Objective: To investigate the expression of EGFR and its relationship in amniotic fluid and placenta of chorioamnionitis patients. Methods: The expression of EGFR in each group was determined by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). Results: ① The intensity of EGFR expression in chorioamnionitis group was significantly higher than that in control group. Amniotic fluid meconium staining group compared with the control group, EGFR value increased. ② The level of EGFR in amniotic fluid of pregnant women with chorioamnionitis was positively correlated with the expression of EGFR protein in placenta (r = 0.57, P <0.05). Conclusion: The abnormal expression of EGFR in amniotic fluid and placenta of chorioamnionitis patients may play an important role in the pathogenesis of chorioamnionitis.