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目的探讨晚期妊娠中有妊娠合并症或并发症孕妇的血浆D-二聚体(DD)的水平变化及临床意义。方法分别检测30例对照组(健康非妊娠妇女)和356例住院分娩孕妇(分为正常妊娠组180例,妊娠合并症组55例,妊娠并发症组121例)的DD值。结果正常妊娠组、妊娠合并症组、妊娠并发症组与对照组相比,其血浆DD水平均明显升高(P<0.05,P<0.01);而妊娠高血压、妊娠期糖尿病、胎盘早剥的孕妇,其血浆DD水平均明显高于正常妊娠组(P均<0.05);而血小板减少、缺铁性贫血、前置胎盘、胎膜早破、ICP与正常妊娠组相比差异无统计学意义(P>0.05)。结论监测孕妇血浆DD值有重要临床意义,可以筛查出妊娠高血压、妊娠期糖尿病、胎盘早剥等高危孕妇并及时干预。
Objective To investigate the changes and clinical significance of plasma D-dimer (DD) levels in pregnant women with gestational complications or complications in late pregnancy. Methods The DD values of 30 pregnant women (control group) and 356 pregnant women (divided into normal pregnancy group (n = 180), pregnancy complications group (n = 55) and pregnancy complications group (n = 121) Results Compared with the control group, the levels of plasma DD in normal pregnancy group, pregnancy complicating group and pregnancy complications group were significantly increased (P <0.05, P <0.01); while pregnancy-induced hypertension, gestational diabetes mellitus, Of the pregnant women, the plasma DD levels were significantly higher than the normal pregnancy group (P all <0.05); thrombocytopenia, iron deficiency anemia, placenta previa, premature rupture of membranes, ICP and no difference in normal pregnancy group Significance (P> 0.05). Conclusion Monitoring of plasma DD in pregnant women has important clinical significance. It can screen pregnant women with high risk of pregnancy-induced hypertension, gestational diabetes, and placental abruption and timely intervention.