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基质金属蛋白酶(MMPs)是一组能降解所有细胞外基质的蛋白溶解酶家族,亦是致类风湿性关节炎(RA)不可逆关节损害的主要原因之一。而所有MMPs的活性均可被相应的组织金属蛋白酶抑制剂(TIMPs)所抑制。下调MMPs和(或)上调TIMPs是治疗类风湿性关节炎的重要策略之一。
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade all extracellular matrix and are also one of the major causes of irreversible joint damage in rheumatoid arthritis (RA). The activity of all MMPs can be inhibited by the corresponding tissue inhibitors of metalloproteinases (TIMPs). Down-regulation of MMPs and / or upregulation of TIMPs is one of the important strategies for the treatment of rheumatoid arthritis.