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目的:判定北京基因型结核分枝杆菌在中国结核分枝杆菌复合群中的群结构特征。设计:采用spoligotyping和IS6110限制性片段长度多态性(RFLP)方法对441株分枝杆菌分离株行基因分型鉴定。分离株取自2000年中国结核病流行病学抽样调查,耐药性和流行病学资料已知。结果:spoligotyping法共鉴定408株结核分枝杆菌,其中北京基因型结核分枝杆菌占64.9%(265/408)。卡方检验北京基因型结核分枝杆菌在性别、年龄、地区所占的比例没有统计学显著性差异,但是耐多药(MDR)有统计学显著性差异。北京基因型在耐多药和药物敏感性分离株中所占的比例分别为77.8%(42/54)和60.2%(213/354)。多元回归分析提示北京基因型与不同地区存在联系,但与耐多药无关。结论:北京基因型结核分枝杆菌在中国流行至少50年,并且与地区有关。
Objective: To determine the population structure of Mycobacterium tuberculosis genotypes in Mycobacterium tuberculosis complex in China. DESIGN: 441 mycobacteria isolates were genotyped by spoligotyping and IS6110 restriction fragment length polymorphism (RFLP). The isolates were taken from a sample of epidemiological surveys of tuberculosis in China in 2000, and drug resistance and epidemiological data are known. Results: 408 strains of Mycobacterium tuberculosis were identified by spoligotyping method, of which 64.9% (265/408) were genotypes of Mycobacterium tuberculosis in Beijing. There was no statistically significant difference in the proportion of genotypes of M. tuberculosis in Beijing by chi-square test, but there was a statistically significant difference in multi-drug resistance (MDR). Beijing genotypes accounted for 77.8% (42/54) and 60.2% (213/354), respectively, in multidrug-resistant and drug-susceptible isolates. Multivariate regression analysis suggested that genotypes in Beijing were related to different regions, but not to MDR. Conclusion: Mycobacterium tuberculosis in Beijing is endemic for at least 50 years in China and is related to the region.