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目的 :探讨肠缺血 再灌注损伤时 ,肺表面活性物质及脂质过氧化物 (LPO)含量的改变及其意义 ,以及黄芪在缺血 再灌注过程中对肺损伤的保护作用。方法 :复制家兔肠损伤模型 ,测定血浆和肺组织LPO及肺表面活性物质含量变化 ,同时计算肺系数及进行肺病理学检查 ,并观察黄芪对LPO及肺表面活性物质含量的影响。结果 :静脉给予黄芪注射液可提高肺表面活性物质含量 ,减少LPO的生成 ,对缺血 再灌注引起的肺组织损伤有明显的保护作用。结论 :肺表面活性物质下降可能与LPO上升有关 ,黄芪通过其稳膜作用能减轻或在一定程度上防止缺血 再灌注时肺损伤的发生和发展
Objective : To investigate the changes of pulmonary surfactant and lipid peroxide (LPO) content and its protective effect on lung injury during ischemia-reperfusion. METHODS: Rabbit intestinal injury models were duplicated. Changes in LPO and lung surfactant content in plasma and lung tissue were determined. Lung coefficient and lung pathology were also calculated. The effects of Astragalus on LPO and pulmonary surfactant were also observed. Results: Intravenous administration of Astragalus membranaceus injection could increase the content of pulmonary surfactant and decrease the production of LPO, which had a significant protective effect on lung tissue injury caused by ischemia-reperfusion. Conclusion : The decrease of pulmonary surfactant may be related to the increase of LPO. Astragalus can reduce or prevent the occurrence and development of lung injury during ischemia and reperfusion to some extent through its stabilization effect.