在感染、严重外伤和烧伤之后,机体有一个突出的代谢反应──蛋白质从骨骼肌转向肝内、刺激糖异生和蛋白质合成。起初认为这种反应是应急激素所致。但近来研究表明:细胞因子,即白介素1、2、6和肿瘤坏死因子(TNF)等,是这些反应的重要介质。已知TNF能诱导肝急相蛋白合成,给大鼠长期输入TNF能使肝细胞明显增加。作者用重200g雄性Wistar大鼠给予全肠外营养(TPN),并于TPN液中加入人重组 After infection, severe trauma and burns, the body has a prominent metabolic reaction - the protein turns from skeletal muscle to liver, stimulating gluconeogenesis and protein synthesis. At first thought this response is caused by emergency hormones. However, recent studies have shown that cytokines, interleukin 1, 2, 6 and tumor necrosis factor (TNF), are important mediators of these responses. It is known that TNF induces the synthesis of hepatic phase proteins, and the long-term input of TNF into rats can significantly increase the number of hepatocytes. The author used 200g male Wistar rats to give total parenteral nutrition (TPN), and in the TPN solution by adding human recombinant