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干细胞研究于1999年度和2000年度连续两次被美国科学杂志评为世界十大科技成果之一,成为当今世界生命科学研究最前沿、最活跃的领域之一.由于(1)干细胞有自我更新和向多种细胞分化的能力,将为组织器官再生提供新的细胞来源途径;(2)目前研究认为,成年组织含有三个不同层次的细胞,即干细胞、祖细胞和成熟细胞,探讨疾病情况下干细胞、祖细胞的分化将很可能从细胞发育学的角度阐明一些疾病的发病机制;(3)研究如何促进干/祖细胞想所在组织的成熟细胞分化将可能成为疾病防治研究的新思路.因此,干/祖细胞研究具有重要的理论意义和潜在的临床应用价值.消化系统由多个器官组成,近年来国外对消化系统干/祖细胞的研究较多,为了了解国外消化系统干/祖细胞的研究状况、促进我国在该领域的研究,我们对消化系统主要器官胃、肠、肝脏及胰腺的干/祖细胞的研究文献进行了综述.
Stem cell research has been ranked as one of the top 10 scientific and technological achievements by the American Science Journal twice in 1999 and 2000. It has become one of the foremost and most active fields in the life science research in the world today, as (1) stem cells are self-renewing and The ability to differentiate into multiple cells will provide a new source of cells for organ regeneration. (2) The current study suggests that adult tissues contain three different levels of cells, stem cells, progenitor cells and mature cells, Differentiation of stem cells and progenitor cells will probably elucidate the pathogenesis of some diseases from the perspective of cell development. (3) Studying how to promote the differentiation of stem cells from stem / progenitor cells in the tissue where they are intended may become a new way of thinking in disease prevention and treatment. , Stem / progenitor cell research has important theoretical significance and potential clinical application value.Digestive system consists of multiple organs, foreign countries in recent years, more research on the digestive system stem / progenitor cells, in order to understand the foreign digestive system stem / progenitor cells Research status, and promote our research in this area, we are the main organs of the digestive system of stomach, intestine, liver and pancreas stem / progenitor The study reviewed the literature.