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端粒酶对维持端粒长度和基因组稳定起着决定作用。在干细胞、恶性肿瘤细胞内,端粒酶的表达水平升高,造成端粒长度保持不变,甚至增长,使得这些细胞永生化成为可能,并且可以为肿瘤干细胞的形成创造条件。hTERT(human telomerase reverse transcriptase)是端粒酶的催化亚基,它的表达与否对端粒酶的激活起着限制作用。有关hTERT基因转录调控机制的研究在近几年取得了较大进展,这对揭示肿瘤发生过程有很大意义,并且为肿瘤的定向治疗提供了一个有效的靶点。
Telomerase plays a decisive role in maintaining telomere length and genomic stability. In stem cells and malignant cells, the expression level of telomerase increases, resulting in telomere length remains unchanged or even increased, making these cells immortalized possible, and can create conditions for the formation of cancer stem cells. hTERT (human telomerase reverse transcriptase) is the catalytic subunit of telomerase, its expression or not limits the activation of telomerase. Research on the mechanism of transcriptional regulation of hTERT has made great progress in recent years, which is of great significance to reveal the process of tumorigenesis, and provides an effective target for the targeted therapy of tumors.