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目的 :分析影响儿童青少年的胰岛素敏感性的遗传和环境因素 ,并探讨其中体质指数 (bodymassindex ,BMI)、年龄和性别的作用。方法 :选择 5～ 18岁同性别双生子 2 96对 ,平均年龄 (12 4± 3 5 )岁 ,其中同卵双生子(MZ) 2 2 3对 ,异卵双生子 (DZ) 73对。在DNA卵性鉴定基础上 ,应用Mx软件模型拟合分别计算BMI调整前后稳态模型胰岛素抵抗指数 (homeostasismodelassessmentinsulinresistanceindex ,HOMAIR)和 β细胞功能指数 (HOMAβ cellfunctionindex ,HBCI)的遗传度 ,并检验年龄和性别对于模型的作用。结果 :HOMAIR与年龄、性别和BMI相关 ,HBCI与年龄相关 ,遗传分析HOMAIR、HBCI的模型为ACE ,BMI调整前后HOMAIR男女生遗传度不同 ,HB CI无明显变化。调整后HOMAIR、HBCI遗传度分别为 0 .2 5、0 .2 4。结论 :儿童青少年人群中HOMAIR、HBCI受遗传和环境因素共同作用 ,环境因素的影响似乎更大 ;BMI是影响机体胰岛素敏感性的重要因素 ;年龄和性别对遗传度的影响可能不大。
OBJECTIVE: To analyze the genetic and environmental factors that affect insulin sensitivity in children and adolescents and explore the role of body mass index (BMI), age and gender. Methods: A total of 2 96 pairs of twins (aged 5-18 years) were selected, with an average age of (12 4 ± 3 5) years old, including 213 pairs of identical twin (MZ) and 73 pairs of differential twin (DZ). On the basis of DNA oocyte identification, Mx software model fitting was used to calculate the hereditary degree of homeostasis of senescence resistance index (HOMAIR) and β-cell function index (HBCA) before and after BMI adjustment, and the age and sex The role of the model. Results: HOMAIR was related to age, sex and BMI, HBCI was related to age, genetic analysis HOMAIR, HBCI model was ACE, HOMAIR male and female had different hereditary degrees before and after BMI adjustment, HB CI no significant change. The adjusted HOMAIR and HBCI heritabilities were 0.25, 0.24 respectively. CONCLUSION: HOMAIR and HBCI in children and adolescents are affected by both genetic and environmental factors and environmental factors seem to be more influential. BMI is an important factor affecting the body’s insulin sensitivity. Age and sex may not have a significant impact on heritability.