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目的 探讨支气管哮喘发病机制中抑制性T淋巴细胞的控制作用。方法 用ELISA法、细胞生物活性法及流式细胞仪检测技术。结果 ①病人CD8+ T细胞对抗原递呈的抑制作用明显低于对照组 (P <0 .0 5 ) ;②病人CD4 + CD4 5RA+ T细胞对B细胞产生免疫球蛋白的抑制作用明显低于对照组 (P <0 .0 1) ;③病人CD8+ T细胞对嗜酸性粒细胞产生ECP的抑制作用明显低于对照组 (P <0 .0 5 ) ;④健康人CD8+ 与CD4 + T细胞之间凋亡现象差别明显 (P <0 .0 5 ) ,而哮喘病人无此差别。结论支气管哮喘发病过程中抑制性T淋巴细胞表现出抑制功能的降低
Objective To investigate the role of suppressor T lymphocytes in the pathogenesis of bronchial asthma. Methods ELISA, cell biological activity and flow cytometry technology. Results ① The inhibitory effect of CD8 + T cells on antigen presentation was significantly lower than that of the control group (P <0.05). ② The inhibitory effect of CD4 + CD4 + CDRA + T cells on B cells immunoglobulin was significantly lower than that of the control group (P <0.01) .③The inhibitory effect of CD8 + T cells on eosinophil ECP was significantly lower than that of the control group (P <0.05); ④The apoptosis of CD8 + and CD4 + T cells The difference was statistically significant (P <0.05), but no difference in asthma patients. Conclusions Inhibitory T lymphocytes showed decreased inhibitory function in the pathogenesis of bronchial asthma