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目的:研究大鼠静脉注射银杏内酯B注射液后的药代动力学。方法:采用LC-MS法测定银杏内酯B经时血药浓度,采用DAS2.0实用药代动力学程序计算其药代动力学参数。结果:大鼠单次静脉注射低、中、高(0.75、3.75、14.0 mg/kg)三个剂量银杏内酯B注射液,银杏内酯B主要药代动力学参数:Tmax均为(0.083±0)h,Cmax均值分别为(422.312±14.203)、(1608.467±226.677)、(1987.036±237.202)μg/L,AUC0-t均值分别为(533.833±114.943)、(1786.029±137.066)、(1943.44±415.892)μg.h/L。结论:各剂量组血药浓度试验数据经拟和优度分析,药物消除符合三室模型,AUC0-t、AUC0-∞、Cmax随剂量的增加而不成比例增加,说明银杏内酯B注射药液给药后在大鼠体内呈非线性动力学消除过程。
Objective: To study the pharmacokinetics of ginkgolide B injection in rats. Methods: The plasma concentrations of ginkgolide B were determined by LC-MS. The pharmacokinetic parameters of ginkgolide B were calculated by DAS 2.0 pharmacokinetic program. Results: The main pharmacokinetic parameters of Ginkgolide B were as follows: (0.083 ± The average AUC0-t values were (533.833 ± 114.943), (1786.029 ± 137.066), (1943.44 ± 415.892) μg.h / L. Conclusions: The data of plasma concentration in each dose group were analyzed by goodness-of-fit and goodness-of-fit analysis, and the drug elimination accorded with three-compartment model. The AUC0-t, AUC0-∞ and Cmax increased proportionally with the increase of dose, indicating that Ginkgolide B After the drug in rats showed a nonlinear kinetic elimination process.