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目的 检测子痫前期(PE)孕妇血清脂肪因子补体C1q肿瘤坏死因子相关蛋白(CTRP)3、CTRP9水平,并分析其与糖代谢及脂代谢指标水平的相关性.方法 选取2016年1月至2018年3月在深圳市龙华区人民医院同胜社区服务中心产检分娩的轻度子痫前期孕妇96例,重度子痫前期孕妇90例,另选取健康孕妇100例为对照组.采用酶联免疫吸附法检测血清CTRP3、CTRP9水平;利用全自动生化仪检测甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、高密度脂蛋白胆固醇(HDL)、游离脂肪酸(FFA)、空腹血糖(FPG)水平,利用全自动化学发光仪检测空腹胰岛素水平(FINS)水平.计算胰岛素抵抗指数(HOMA-IR).比较三组之间上述指标的差异,并采用Pearson分析CTRP3、CTRP9水平与糖脂代谢指标的相关性 重度组与轻度组PE患者血清CTRP3、CTRP9水平均显著低于对照组(P＜0.05),重度组PE患者血清CTRP3、CTRP9水平显著低于轻度组(P＜0.05);重度组与轻度组PE患者血清脂代谢指标FFA、TG、TC、LDL均显著高于对照组(P＜0.05),HDL水平均显著低于对照组(P＜0.05);重度组PE患者血清脂代谢指标FFA、TG、TC、LDL均显著高于轻度组(P＜0.05),HDL水平显著低于轻度组(P＜0.05).重度组与轻度组PE患者血清糖代谢指标FPG、FINS、HOMA-IR均显著高于对照组(P＜0.05);重度组PE患者血清糖代谢指标FPG、FINS、HOMA-IR均显著高于轻度组(P＜0.05).Pearson分析结果显示,PE患者血清CTRP3、CTRP9水平与FFA、TG、TC、FPG、FINS、HOMA-IR水平均呈负相关(P＜0.05),与HDL水平呈正相关(P＜0.05).结论 PE患者血清CTRP3、CTRP9水平下降,与FFA、TG、TC、FPG、FINS、HOMA-IR水平呈负相关,与HDL水平呈正相关,可能通过影响孕妇糖脂代谢,间接参与PE发病及病情进展过程.“,”Objective To detect the levels of serum fatty factor complement C1q tumor necrosis factor-related protein (CTRP) 3 and CTRP9 in pre-eclampsia (PE) pregnant women,and to analyze their correlations with the levels of glucose metabolism and lipid metabolism indexes.Methods From January 2016 to March 2018,96 pregnant women with mild pre-eclampsia and 90 pregnant women with severe preeclampsia were selected,another 100 healthy pregnant women were selected as control group.The levels of serum CTRP3 and CTRP9 were detected by enzyme linked immunosorbent assay (ELISA);the levels of triglyceride (TG),cholesterol (TC),low density lipoprotein cholesterol (LDL),high density lipoprotein cholesterol (HDL),free fatty acid (FFA),and fasting blood glucose (FPG) were measured by automatic biochemical analyzer;fasting insulin level (FINS) was measured by automatic chemiluminescence instrument.The insulin resistance index (HOMA-IR) was calculated and the differences among the three groups were compared.Pearson was used to analyze the correlation between the levels of CTRP3 and CTRP9 and the indexes of glycolipid metabolism.Results The serum CTRP3 and CTRP9 levels of PE patients in severe group and mild group were significantly lower than those in control group (P ＜ 0.05),and serum CTRP3 and CTRP9 levels in severe PE patients were significantly lower than those in mild PE patients (P ＜ 0.05);the serum lipid metabolism indexes levels of FFA,TG,TC,and LDL of PE patients in severe group and mild group were significantly higher than those in control group (P ＜ 0.05),and HDL level was significantly lower than that of the control group (P ＜ 0.05);the levels of serum lipid metabolism indexes FFA,TG,TC,and LDL of PE patients in severe group were significantly higher than those in mild group (P ＜ 0.05),and the level of HDL was significantly lower than that in mild group (P ＜ 0.05).The levels of serum glucose metabolism indexes FPG,FINS,and HOMA-IR of PE patients in severe group and mild group were significantly higher than those in control group (P ＜ 0.05);the levels of FPG,FINS,and HOMA-IR in severe PE patients were significantly higher than those in mild PE patients (P ＜ 0.05).Pearson test showed that serum CTRP3 and CTRP9 levels in PE patients were negatively correlated with FFA,TG,TC,FPG,FINS,and HOMA-IR levels (P ＜ 0.05),and positively correlated with HDL level (P ＜ 0.05).Conclusions The levels of serum CTRP3 and CTRP9 are decreased in PE patients,which is negatively correlated with FFA,TG,TC,FPG,FINS,and HOMA-IR levels,and positively correlated with HDL level.They may be indirectly involved in the pathogenesis and progression of PE by affecting the glycolipid metabolism in pregnant women.