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目的:探讨复方鳖甲软肝片联合阿德福韦酯对乙肝肝硬化患者肝功能和乙肝血清标志物水平的影响。方法:选择我院进行治疗的乙肝肝硬化患者60例,随机分为实验组与对照组,每组30例。对照组患者给予阿德福韦酯治疗,实验组患者在对照组基础上给予复方鳖甲软肝片治疗。比较治疗前后两组患者血浆白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、血清总胆红素(TBIL)及凝血酶源时间(PT)水平、不良反应、HBe Ag转阴率、HBV-DNA转阴率及HBe Ag血清转化率。结果:与治疗前相比,两组患者治疗后的血清ALB水平均升高,血清ALT、TBIL及PT水平均降低(P<0.05);与对照组相比,实验组患者的血清ALB水平、HBe Ag转阴率、HBV-DNA转阴率及HBe Ag血清转化率较高,血清ALT、TBIL、PT水平、不良反应发生率较低(P<0.05)。结论:复方鳖甲软肝片联合阿德福韦酯较单用阿德福韦酯可更有效改善乙肝肝硬化患者的肝功能,并抑制病毒的复制,且安全性较高。
Objective: To investigate the effect of Fufang Biejia Ruangan Pian combined with adefovir dipivoxil on the liver function and the serum level of hepatitis B in patients with hepatitis B cirrhosis. Methods: Sixty patients with hepatitis B cirrhosis who were treated in our hospital were randomly divided into experimental group and control group, with 30 cases in each group. Patients in the control group were treated with adefovir dipivoxil, and patients in the experimental group were given Fufang Biejia Ruangan Pian on the basis of the control group. The changes of serum albumin (ALB), alanine aminotransferase (ALT), total serum bilirubin (TBIL) and time of thrombin (PT), adverse reactions, HBV-DNA negative rate and HBeAg seroconversion rate. Results: Compared with those before treatment, the levels of serum ALB in both groups increased and the levels of ALT, TBIL and PT in serum decreased (P <0.05). Compared with the control group, serum ALB level, HBeAg negative rate, HBV-DNA negative rate and HBeAg seroconversion rate, serum ALT, TBIL, PT levels, adverse reactions were lower (P <0.05). Conclusion: Fufang Biejia Ruangan Pian combined with adefovir dipivoxil can be more effective than adefovir dipivoxil alone in improving liver function and inhibiting viral replication in hepatitis B cirrhosis patients with high safety.