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[目的]回顾性分析食管癌根治术后局部区域复发患者行挽救性放化疗的疗效。[方法]26例根治术后局部区域复发的患者接受挽救性放化疗。中位放疗剂量60 Gy(50～70Gy),同步周剂量紫杉醇(50mg/m~2)联合顺铂(25mg/m~2)化疗。[结果]全组患者中位随访时间16个月,5例仍存活的患者中位随访期25个月。1、2年生存率分别为53.8%及19.2%,中位生存时间13个月。≥3级毒性反应主要为白细胞减少(26.9%)、食管炎(23.1%)及恶心(19.2%)。[结论]食管癌术后局部区域复发行同步放化疗安全有效,可明显延长部分患者的生存期。
[Objective] To retrospectively analyze the curative effect of salvage radiotherapy and chemotherapy in patients with local recurrence of esophageal cancer after radical operation. [Method] Twenty-six patients undergoing radical operation with local recurrence underwent salvage radiotherapy and chemotherapy. The median dose of radiotherapy was 60 Gy (50-70 Gy), paclitaxel (50 mg / m 2) and cisplatin (25 mg / m 2) simultaneously. [Results] The median duration of follow-up was 16 months in all patients and the median follow-up time was 25 months in 5 patients who survived. The 1-year and 2-year survival rates were 53.8% and 19.2% respectively, and the median survival time was 13 months. Grade 3 toxicity was mainly leukopenia (26.9%), esophagitis (23.1%) and nausea (19.2%). [Conclusions] Concurrent esophageal cancer recurrence in local area after concurrent chemoradiotherapy is safe and effective, which can significantly prolong the survival of some patients.