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目的探讨糖尿病大鼠皮肤的隐形损害现象,以及磷酸化的表皮生长因子受体(P-EGFR)在糖尿病皮肤中的表达与这种隐形损害的关系。方法对比观察不同病期的糖尿病大鼠模型背部和尾巴皮肤组织学改变以及超微结构变化,用免疫组化及蛋白印迹的方法检测P-EGFR在糖尿病大鼠皮肤中的表达。结果糖尿病大鼠皮肤存在组织学和超微结构的改变,PEGFR在皮肤组织中的表达下降。结论 P-EGFR在糖尿病大鼠皮肤组织中表达下调可能与糖尿病皮肤损害的发生有关。
Objective To investigate the invisible damage of the skin of diabetic rats and the relationship between the expression of phosphorylated epidermal growth factor receptor (P-EGFR) in diabetic skin and the invisible damage. Methods The histological changes and ultrastructure changes of the dorsal and tail skin of diabetic rats at different stages were observed and compared. The expression of P-EGFR in the skin of diabetic rats was detected by immunohistochemistry and Western blotting. Results There was histological and ultrastructural changes in the skin of diabetic rats, and the expression of PEGFR in skin tissues decreased. Conclusion The down-regulation of P-EGFR in the skin of diabetic rats may be related to the occurrence of diabetic skin lesions.